antioxidant molecules  (MultiTarget Pharmaceuticals)

Journal: Advanced Healthcare Materials

Article Title: Ovarian Function Restoration with Biomimetic Scaffold Incorporating Angiogenic Molecules and Antioxidant in Chemotherapy‐Induced Perimenopausal Model

doi: 10.1002/adhm.202403944

Figure Lengend Snippet: The schematic illustration of hESC‐MPCs laden biomimetic scaffold incorporating antioxidant and angiogenic molecules restorates the chemotherapy‐induced premature ovarian insufficiency in mice. The biomimetic scaffold containing PDRN and melatonin provides higher hESC‐MPCs adhsion, immune moduation, and angiogenesis for ovarian function restoation.

Article Snippet: Baek , D. R. Lee , D. K. Han , Ovarian Function Restoration with Biomimetic Scaffold Incorporating Angiogenic Molecules and Antioxidant in Chemotherapy‐Induced Perimenopausal Model . Adv.

Techniques:

Journal: Molecules

Article Title: Antioxidant Cardioprotection against Reperfusion Injury: Potential Therapeutic Roles of Resveratrol and Quercetin

doi: 10.3390/molecules27082564

Figure Lengend Snippet: Natural Antioxidants.

Article Snippet: The paradigm of a multitarget therapy based on an association of different antioxidant molecules should be expected to improve the abrogation of oxidative damage and related effects derived from ROS burst, particularly occurring early at the onset of reperfusion.

Techniques: Activity Assay, Membrane, Activation Assay, Inhibition, Expressing

Journal: Molecules

Article Title: Antioxidant Cardioprotection against Reperfusion Injury: Potential Therapeutic Roles of Resveratrol and Quercetin

doi: 10.3390/molecules27082564

Figure Lengend Snippet: Synthetic antioxidants.

Article Snippet: The paradigm of a multitarget therapy based on an association of different antioxidant molecules should be expected to improve the abrogation of oxidative damage and related effects derived from ROS burst, particularly occurring early at the onset of reperfusion.

Techniques: Activation Assay, Activity Assay, Inhibition, Protein-Protein interactions, Binding Assay

Journal: Molecules

Article Title: Antioxidant Cardioprotection against Reperfusion Injury: Potential Therapeutic Roles of Resveratrol and Quercetin

doi: 10.3390/molecules27082564

Figure Lengend Snippet: Representation of resveratrol cardioprotective effect. Resveratrol activates the Nrf2 signaling pathway, increasing the expression of antioxidant enzymes. It also reduces the expression of pro-apoptotic proteins, such as caspase 3, via the PI3K/Akt pathway. Other effects are the reduction of inflammation and ferroptosis, which has been associated with reduced expression of TNFα, Nf κ B, TfR1, and increased activity of GPX4 after administration of resveratrol. The activation of SIRT1 is related to a decrease in intramitochondrial calcium concentration, which diminishes mitochondrial ROS production.

Article Snippet: The paradigm of a multitarget therapy based on an association of different antioxidant molecules should be expected to improve the abrogation of oxidative damage and related effects derived from ROS burst, particularly occurring early at the onset of reperfusion.

Techniques: Expressing, Activity Assay, Activation Assay, Concentration Assay

Journal: Molecules

Article Title: Antioxidant Cardioprotection against Reperfusion Injury: Potential Therapeutic Roles of Resveratrol and Quercetin

doi: 10.3390/molecules27082564

Figure Lengend Snippet: Representation of quercetin cardioprotective effect. Quercetin acts through the inhibition of the enzymes xanthine oxidase, NADPH oxidase and the Fenton reaction, mechanisms leading to a decrease in ROS production. In addition, it acts by activating the selenoprotein TrxR2, which has a powerful antioxidant effect by inactivating ROS. All these mechanisms lead to a decrease in oxidative stress.

Article Snippet: The paradigm of a multitarget therapy based on an association of different antioxidant molecules should be expected to improve the abrogation of oxidative damage and related effects derived from ROS burst, particularly occurring early at the onset of reperfusion.

Techniques: Inhibition